Based on my experience a tuning box can work fine with the MED 17, as long as the tuning box "map" isn't that aggressive. I've known (or at least heard of, not my own experience) for tuning boxes on the MED 17 to cause erratic performance. I've got my own opinions on that.
For sure, a remap can provide a much better experience and level of performance. I was dead against Tuning Boxes until I actually tested one on my A45 (quickly changed my opinion based on my testing). It was ultimately replaced with an ECU remap and performed better as expected. I'll just follow the same process this time.... just for information and comparison on a different platform.
In respect to custom vs generic map....
We (several of us in the A45 community) tested 5 different maps from 5 totally different MB tuners.
Whilst there were slight differences in the driveability, none were better - they were just different, we logged the mother out of these cars. With all performance logs you couldn't get a hair between them. We then took them down Santa Pod and on one occasion 4 of cars were within 2/100ths of each other. lol You literally couldn't pull them apart.
IIRC Out of the total of 5, 2 were custom and 3 were the tuners generic tunes.
Again, assuming a level playing field of platform and ECU tuning skill / knowledge, at Stage 1 I suspect real world differences are negligible.
At the end of the day we may all have our own preferred methods and tuners, and that is absolutely fine. 
P.S. Thanks for the comment about the project thread. 